Loss of a Job - It is an unpleasant experience in life to lose a job. Our heroes often face unpleasant experiences. This can be shown in books in many ways.
Loss of Powers
Loss of Support (monetary, person, or emotional)
Loss of Sense of Comfort
Loss of Sense of Balance
Loss of Sense of Safety

Addition to the Family - Whether this be of the human type in the form of a bundle of joy, or the animal type with a new pet in the family.
New Sidekick
New Superpower
New Gadget
New Love Connection

Same-ole, Same-ole - Do you feel like you're doing the same thing every single day? This can even be used in your stories!
Character stuck in a time loop of an hour, day, month, etc.
Character rescuing the same person every day (and subsequently having many, many different reasons why this may be going on)
Character getting bored of their daily routine, and branching out in some wild way.